Most heartworm preventatives contain macrocyclic lactones at a dose that kills microfilariae and ensures adequate protection for about 1 month, i.e. This is however not trivial, and also risky for the same reason. The infection has first to be treated with adequate curative anthelmintics before preventative products are administered. Consequently, heartworm preventatives are usually not administered to pets that are already infected with adult worms (hence the periodic diagnostic tests), because the risk of serious complications is real. If this happens, such dead worms may block lung vessels, which can be seriously harmful, even fatal for the pet. Preventatives may kill a few adult worms, but won't kill all of them. These preventative medicines are different from those curative anthelmintics that kill the adult worms. Heartworm preventatives stop development of microfilariae to adult worms but do not cure infections with adult worms. As more dogs are tested it is likely that the mutation is discovered in other breeds, or that the frequencies change. The only way to be sure that a dog is affected or not is to test for it. Other less affected breeds are: Old English Sheepdog, Border Collie, Berger Blanc Suisse, Bobtail, Wäller. The breeds more affected by this mutation are (% frequency): Collie (70%), Long-haired Whippet (65%), Australian Shepherd (50%, also mini), McNab (30%), Silken Windhound (30%), English Shepherd (15%), Shetland Sheepdog (15%), English Shepherd (15%), German Shepherd (10%), Herding Breed Cross (10%). Besides Collies, other dog breeds have shown similar problems, although the MDR-1 mutation has not been confirmed in all of them. This is the case for Collies and related breeds, which have a mutation in the MDR-1 gene that affects the blood-brain barrier and makes it more permeable to such compounds than in dogs without this mutation. Consequently dosing must be as accurate as possible. They can suffer more or less serious adverse effects if treated at dose rates slightly higher than the recommended ones. emodepside) that can cross the blood-brain barrier. Dogs of some breeds do not tolerate macrocyclic lactones or other medicines (e.g. Learn more about spot-ons and their safety. Never use on small dogs pipettes approved for large dogs. WARNING !!!: Never use on cats pipettes approved only for dogs. Suspected poisoning? Read the article on selamectin safety in this site. Estimated Toxicity Class according to the WHO : not applicable for veterinary medicines.LD50 (acute oral) in rats: >5000 mg/kg (based on selamectin LD50 formulation LD50 n.a.* Can be slightly different in some countries: read the product label! SAFETY Cats, large 15.1 to 22 lbs ~ 6.9 to 10 kg bw: 1 pipette with 1.0 mL (equivalent 8.7 to 6.0 mg/kg selamectin).
Cats, medium 5.1 to 15 lbs ~ 2.30 to 6.8 kg bw: 1 pipette with 0.75 mL (equivalent 19.6 to 6.6 mg/kg >selamectin).Dogs, extremely large, 85.1 to 130 lbs ~ 38.7 to 59 kg bw: 1 pipette with 3.0 mL (equivalent to 9.3 - 6.1 mg/kg selamectin).Dogs, extra large 40 to 85 lbs ~ 18.2 to 38.6 kg bw: 1 pipette with 2.0 mL (equivalent to 13.2 - 6.2 mg/kg selamectin).Dogs, very large 20.1 to 40 lbs ~ 9.2 to 18.1 kg bw: 1 pipette with 1.0 mL (equivalent to 13.2 - 6.6 mg/kg selamectin).Dogs, large 10.1 to 20 lbs ~ 4.6 to 9.1 kg bw: 1 pipette with 0.50 mL (equivalent to 13.0 - 6.6 mg/kg selamectin).Dogs, medium 5.1 to 10 lbs ~ 2.30 to 4.50 kg bw: 1 pipette with 0.25 mL (equivalent to 13.0 - 6.7 mg/kg selamectin).Cats: Ancylostoma tubaeforme, Toxocara cati.Heartworms ( Dirofilaria immitis), monthly heartworm prevention.Dogs: ear mites ( Otodectes cynotis), sarcoptic mange ( Sarcoptes scabiei).INDICATIONS: DOGS and CATS PARASITES CONTROLLED* (spectrum of activity)
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